Regarding the safety of glutathione in the liver, it is said that the levels of glutathione in the liver is critically linked to the liver's capacity to detoxify. This means that the higher the glutathione content, the greater the liver's capacity to detoxify harmful chemicals. Typically, when we are exposed to chemicals like alcohol which can damage the liver, the concentration of glutathione in the liver is substantially reduced. This reduction makes the liver susceptible to damage.
IS IT SAFE TO THOSE PERSONS WITH THYROID PROBLEMS?
Both hypothyroidism and hyperthyroidism are associated with enhanced oxidative stress involving antioxidants.
Reschu, Helsel, et. Al.
Has a direct relationship with free radical formation and inverse relationship with levels of erythrocute glutathione and glutathione peroxidase in human subjects.
Turkish Journal of Endocrinology & Metabolism, Feb.,2001
No toxicities have been reported or suspected as being associated with glutathione.
None known, except for use during some forms of chemotherapy and radiation where antioxidants are contraindicated due to their inhibition of the free radical formation which is an integral part of the therapeutic mechanism.
Nutrient affecting drug CISPLATIN
Nutrient affected by drug and affecting drug HALOPERIDOL
There have been no reports of glutathione overdosage in the literature.
DOSAGE AND ADMINISTRATION
Glutathione is available as a single ingredient dietary supplement or in combination products. Dosage ranges from 50 to 1000mg.
Oral doses of up to 1000 milligrams daily are well tolerated. There are no reports of adverse reactions.
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